The objective of present study was to develop domperidone hydrogel beads for the effective management of emesis as gastro retensive drug delivery. The domperidone beads were prepared by ionotropic gelation methods using sodium alginate, hydroxyl propyl methyl cellolose, carboxy methylcellulose and sodium carboxy methylcellulose in various ratios. The result of FTIR spectra indicated that stability and compatibility of the drug with the polymer used. The formulated hydrogel beads were discrete, spherical with relatively smooth surface and with good flow properties. All prepared hydrogel beads were evaluated for drug entrapment efficiency, percentage yield, in-vitro swelling and in-vitro release study. SCMC loaded hydrogel beads shows the best batch (F5) was 84.96% in 12 hr respectively showing a better controlled release of drug.
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